Endocrine Abstracts

Primary Aldosteronism (PA) is the most prevalent cause of secondary hypertension. The aim of this work was to characterize the diagnostic workup, treatment and follow-up of confirmed PA.The adrenal tumour study group of the Portuguese Society of Endocrinology undertook the first retrospective multicentre study of Portuguese PA patients. Data was gathered from nine Portuguese Endocrinology centres (three in the north, one in the centre and five in the sou...

Thyroid storm (TS) is one extreme of a continuum beginning with thyrotoxicosis. It’s rarely caused by exogenous thyroid hormone intake (ETHI). Aggressive medical therapy is the cornerstone of treatment; nevertheless, it might not be sufficient. Plasmapheresis is an extracorporeal technique that can rapidly lower thyroid hormone levels. The aim of this study was to assess the efficacy of plasmapheresis in TS secondary to ETHI. We evaluated retrospectively all TS cases (Bur...

Introduction: Pheochromocytomas (PHEO) and paragangliomas (PGL) are rare catecholamine-secreting tumors. Some authors proposed that there is a positive linear relationship between tumor size and measurements of metanephrines and an absence of association with catecholamine levels.Objectives: To review and characterize patients diagnosed with PHEO and PGL in Garcia de Orta Hospital. To determine the relationship between tumor size and measurements of urin...

The use of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG–PET) has increased the detection of thyroid incidentalomas (TI). These are associated with a risk of malignancy between 25 and 50%. Some studies show an association between SUVmax uptake and malignancy.The objective of this study was to determine the prevalence of malignancy on 18F-FDG–PET positive thyroid nodules and to evaluate the relatio...

Introduction: In singleton pregnancies, gestational diabetes mellitus (GDM) results in an increased risk for maternal and neonatal complications. In twin pregnancies, however, the effect of GDM on maternal and neonatal complications appears to be different in comparison to singletons. The few studies that investigated the consequences of GDM in twin pregnancies are small and present conficting evidence, with some finding no difference in perinatal outcomes between GDM and non-...

Wearable physical activity monitors are growing in popularity as they provide the opportunity for self-monitoring, real time data collection and data sharing for cardiovascular and sports medicine. However, there are discussions about the accuracy of their energy expenditure estimate. This study examined and compared basal metabolic rate through indirect calorimetry and through wrist-worn devices and bioimpedance. The group consisted of 30 healthy male individuals, professiona...

The Barraquer-Simons syndrome is a rare form of partial symmetric lipodystrophy with involvement of the face and upper body, of unknown cause, characterized by loss of subcutaneous fat in the face and started stretching for the upper body.Case report: Female patient, 26 years old, presenting morphologic change in facies, chest, upper limbs, lower limbs and abdomen since she was 10 years old. Last year, she has increased weight at 30%, with apparent muscl...

Introduction: Craniopharyngiomas are intracranial tumors that develop from Rathke’s pouch rests of epithelium. They have a bimodal age distribution, with peak incidence at childhood and in the adult/elderly, although in our series we have more patients in a middle peak. Usually they are benign but responsible for significant morbidity, particularly when located near critical structures such as optic chiasm, pituitary gland and hypothalamus, and thus might cause visual, ne...

Connexins are a proteins critically involved in the formation of gap junction, which connect cells with each other and enable the exchange of small compounds and, besides having a role independently of gap junction formation. At least, in the anterior pituitary two cellular networks have already been identified, one of them is composed of the endocrine inactive folliculo-stellate cells and the second one is the GH-producing somatotroph cell network. It is supposed that gap jun...

Objectives: We aimed to develop a registry for the rare genetic diseases Wolfram (WS), Alstrom (AS), Bardet Biedl (BBS) and other diabetes syndromes, containing clinical, genetic diagnostic and outcome data. The purpose is to establish the natural history of these diseases; to assess clinical management; to characterize cohorts for future clinical trials; and to establish genotype phenotype relations. This abstract describes the first 50 patients recruited.<p class="abstex...